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What is chronic obstructive pulmonary disease (COPD)?

COPD is a lung condition that makes breathing difficult. It happens when your lungs become damaged. Common signs include:

• Trouble catching your breath

• Daily, persistent coughing with mucus

• A whistling sound when breathing (wheezing)

If you have COPD, your doctor will typically prescribe medications. These may include medications that open your airways or steroid inhalers to reduce inflammation.

COPD patient with breathing device over nose/mouth

What is the study drug and purpose of the study?

By comparing the investigational study drug to standard COPD treatments, we hope to learn if it works better, the same or not as well as current treatments. The investigational study drug blocks two proteins (IL-4 and IL-13) that can cause inflammation in your lungs when you have COPD. By blocking these proteins, the investigational study drug may help reduce lung inflammation and improve your breathing.

Can I participate?

Study details

Duration & visits

Up to 40 weeks (about 9 months) with approximately nine (9) onsite study visits lasting for a few hours each

Participants & locations

Approximately 218 participatns across nearly 30 countries

What can you expect during the study?

At your appointments, the following may be reviewed:

Physical exam including height, weight and vital signs

Walking test for 6 minutes

Heart activity with ECG

Checks your heart’s electrical activity using electrodes place on your skin.

Lung activity with spirometry

A breathing test that measures the total amount of air you can breathe out from your lungs and how fast you can blow it out.

Lung scans with CT

This test takes special pictures of your lungs. Three (3) scans will be completed during the study.

Lung inflammation with fractional exhaled nitric oxide (FeNO)

Measures a gas called nitric oxide in your breath. When your lungs are inflamed, they produce more of this gas.

Breathing test with forced oscillation technique (FOT)

This test will check how well your lungs are working while you breathe normally.

Home monitoring

You will receive a wristband to wear and a small device for your bedside table that work together to track: coughing, breathing, sleep patterns, movement.

Additionally, you will need to install a simple app on your phone (or we can provide a phone with the app already installed). The app doesn't collect personal information - it only receives health data from the devices.

Blood and urine tests

Questionnaires

To help provide insight into how your COPD is affecting your quality of life.

FAQs - frequently asked questions:

What is a placebo?

A placebo looks like the investigational study drug being tested and is also given in the same way as the investigational study drug that is being studied, but it does not have any medicine in it.
The investigational study drug and placebo will be provided and administered by injection under the skin every 2 weeks either by yourself, at the site or at your home.
You have a 2/3 (67%) chance of receiving the investigational study drug and usual care for 24 weeks or 1/3 (33%) chance of receiving the placebo and usual care for 24 weeks.

Is there a cost to participate?

There is no cost to participate. All study-related exams, study-related medications and study-related medical care are provided. There is no insurance required to take part in this study. You may be compensated for time and travel.

Can I participate?

Find a site near you

Check if you are eligible Enter contact information Select a study center Select best time to contact

Are you a UK resident?

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Version 1.0, Approved June 2025

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