A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
Investigating an Investigational Medication for Moderate-to-Severe Atopic Dermatitis (a Chronic Skin Condition)
Study Overview
This is a parallel group, Phase 3, multinational, multicenter, randomized, double-blind, placebo-controlled, 3-arm study for treatment of participants diagnosed with moderate-to-severe AD on background TCS who have had inadequate response to prior biologic or oral JAKi therapy.
The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for subcutaneous (SC) injection compared with placebo in participants with moderate-to-severe AD aged 12 years and older on background TCS and have had an inadequate response to prior biologic or an oral JAKi therapy.
Study details include:
At the end of the treatment period, participants will have the option to enter the Long-Term Safety Study LTS17367 (RIVER-AD).
The study duration will be up to 56 weeks for participants not entering the long-term safety study (LTS17367 [RIVER-AD]) including a 2 to 4-week screening, a 36-week randomized double-blind period, and a 16-week safety follow-up.
The study duration will be up to 40 weeks for participants entering the long-term safety study (LTS17367 [RIVER-AD]) including a 2 to 4-week screening and a 36-week randomized double-blind period.
The total treatment duration will be up to 36 weeks. The total number of visits will be up to 13 visits (or 12 visits for those entering the long-term safety study LTS17367 [RIVER-AD] study).
Eligibility Criteria
You may be eligible for this study if you meet the following criteria:
- Conditions: Dermatitis Atopic
-
Age: 12 Years
-
Gender: All
Inclusion Criteria:
- Participants must be 12 years of age (when signing informed consent form)
- Diagnosis of AD for at least 1 year (defined by the American Academy of Dermatology Consensus Criteria)
- Documented history prior to screening visit of inadequate response to a biologic AD medication or an oral JAKi therapy.
- v-IGA-AD of 3 or 4 at baseline visit
- EASI score of 16 or higher at baseline
- AD involvement of 10% or more of BSA at baseline
- Weekly average of daily PP-NRS of ≥ 4 at baseline visit.
- Able and willing to comply with requested study visits and procedures
- Body weight ≥25 kg
Exclusion Criteria:
Participants are excluded from the study if any of the following criteria apply:
- Skin co-morbidity that would adversely affect the ability to undertake AD assessments
- Known history of or suspected significant current immunosuppression
- Any malignancies or history of malignancies prior to baseline (with the exception of non-melanoma skin cancer excised and cured >5 years prior to baseline)
- History of solid organ or stem cell transplant
- Any active or chronic infection including helminthic infection requiring systemic treatment within 4 weeks prior to baseline
- Positive for human immunodeficiency virus (HIV), Hepatitis B or hepatitis C at screening visit
- Having active tuberculosis (TB), latent TB, a history of incompletely treated TB, suspected extrapulmonary TB infection, or who are at high risk of contracting TB
- Having received any of the specified therapy within the specified timeframe(s) prior to the baseline visit
- In the Investigator's opinion, any clinically significant laboratory results or protocol specified laboratory abnormalities at screening
- History of hypersensitivity or allergy to any of the excipients or investigational medicinal product (IMP)
The above information is not intended to contain all considerations relevant to a potential participation in a clinical trial
This study investigates the effectiveness and safety of an investigational medication for people with moderate-to-severe atopic dermatitis (AD). Atopic dermatitis is a skin condition that causes red, itchy, and inflamed skin. Participants in this study are those who have not responded well to previous treatments, such as biologic medications or oral JAK inhibitors, while using topical corticosteroids (TCS).
Participants will be randomly assigned to one of three study arms. Some will receive the investigational medication as a subcutaneous injection, while others will receive a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine. The study will include regular check-ups and assessments to monitor the participants' skin condition and overall health.
- Who can participate
- Participants aged 12 years and older.
- Must have moderate-to-severe atopic dermatitis for at least 1 year and a history of inadequate response to biologic or oral JAK inhibitor therapy.
- Must have a validated Investigator Global Assessment for Atopic Dermatitis (v-IGA-AD) score, Eczema Area and Severity Index (EASI) score, and Body Surface Area (BSA) involvement meeting study criteria - Study Details
- Participants will be randomly assigned to one of three study arms to receive either the investigational medication or a placebo.
- The study involves regular visits for health assessments and monitoring - Study Timelines and Visits: The study will last 56 weeks.The study requires 13 visits
Find a Study Location to Connect
,
You have contacted , on
Your message has been sent to the study team at ,
What happens next?
- You can expect the study team to contact you via email or phone in the next few days.
- Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.
You are contacting
Primary Contact
