A Phase 2 Study to Evaluate the Efficacy and Safety of SAR444656 Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa
Study Overview
This is a parallel, Phase 2, 2-arm study to evaluate the efficacy, safety, PK, and biological effects of SAR444656 compared with placebo in adult participants with moderate to severe HS aged ≥18 to 70 years.
Study details include:
- Screening period: up to 4 weeks (30 days)
- Treatment duration: up to 16 weeks
- Follow-up period: up to 4 weeks
- Total study duration: up to 24 weeks
- Number of visits: 14
Eligibility Criteria
You may be eligible for this study if you meet the following criteria:
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Conditions:
Hidradenitis Suppurativa
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Age: Between 18 Years - 70 Years
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Gender: All
Inclusion Criteria:
- Participant with a history of signs and symptoms consistent with HS for at least 1 year prior to baseline.
- Participant must have HS lesions present in at least 2 distinct anatomic areas, one of which must be Hurley Stage II or Hurley Stage III.
- Participant must have had an inadequate response to at least a 3-month treatment of an oral antibiotic for treatment of HS as assessed by the Investigator.
- Participant must have a total AN count of ≥5 at the baseline visit.
- Participant must have a draining tunnel count of ≤20 at the baseline visit.
- Participant must have a CRP >3 mg/L obtained at screening.
- Participant must be willing and able to complete the diary for the duration of the study as required by the study protocol.
- Contraceptive use by men with a partner of childbearing potential and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
Exclusion Criteria:
- Participant with any other active skin disease or condition (eg, bacterial, fungal, or viral infection) that may interfere with assessment of HS.
- Any active or chronic infection requiring systemic treatment (eg, antibiotics, antivirals, antifungals, antihelminthics) within 30 days prior to baseline.
- Known history of or suspected significant suppressed immune response, including history of invasive opportunistic or helminthic infections despite infection resolution or otherwise recurrent infections of abnormal frequency or prolonged duration.
- Participant with history of solid organ transplant.
- Participant with history of splenectomy.
- Participant with history of any malignancy or lymphoproliferative disease, except if the participant has been free from disease for ≥5 years. Successfully treated non-metastatic cutaneous squamous cell carcinoma, basal cell carcinoma, or localized carcinoma in situ of the cervix are allowed.
- Participant with a diagnosis of chronic immune-mediated, inflammatory conditions other than HS
- Participant with family history of sudden death or long QT syndrome.
- Participant with history of congenital or drug-induced long QT syndrome.
- Participant with congestive heart failure (New York Heart Association Class 2 to 4), greater than Class 1 angina pectoris, acute coronary syndrome within prior 6 months, known structural heart disease.
- Participant with history of any major cardiovascular events (eg, myocardial infarction, unstable angina pectoris, coronary revascularization, stroke, or transient ischemic attack) at any time prior to screening.
- Participant with history of ventricular fibrillation, ventricular tachycardia, torsades de pointes, atrial fibrillation, syncope not explained by non-cardiac etiology.
- Participant with uncontrolled hypertension defined as consistent systolic blood pressure ≥150 mmHg or consistent diastolic blood pressure ≥90 mmHg despite antihypertensive medication.
- Participant received prescription topical therapies for the treatment of HS within 14 days prior to the baseline visit.
- Prior or active treatment with any systemic biologic (anti-TNF) therapy, anti-IL17
therapy, anti-IL1/anti-IL1 receptor therapy except for up to 20% of the total study
population. Furthermore, this 20% of biologic-experienced participants must fulfilled
one or more of the following conditions:
- Discontinued due to treatment related toxicity and/or
- Discontinuation is not related to lack or loss of therapeutic response.
The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
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