This study investigates the treatment of moderate-to-severe rheumatoid arthritis (RA) in adults who have not responded adequately to methotrexate (MTX). Rheumatoid arthritis is a condition where the immune system attacks the joints, causing pain and swelling. Participants will receive either the investigational medication or a placebo, in addition to their …
This study investigates the efficacy and safety of an investigational medication compared to a placebo in patients who have undergone a bilateral lung transplant. The condition being studied is chronic lung allograft dysfunction (CLAD), which is a progressive condition affecting lung function after a transplant. Participants will receive either the …
This study investigates the effects of an investigational medication on children and adolescents with prurigo nodularis, a skin condition characterized by itchy nodules. The purpose of this study is to understand how the body processes the medication and to assess its safety in participants aged 6 months to under 18 …
This study investigates the relationship between type 2 diabetes (T2DM) and periodontitis (PD). Type 2 diabetes is a condition where the body does not use insulin properly, leading to high blood sugar levels. Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the …
This study investigates the long-term safety and effectiveness of an investigational medication in adults with moderate-to-severe asthma. Asthma is a condition where the airways in the lungs become narrow and swollen, making it hard to breathe. Participants in this study have already completed a previous study and will continue to …
This study investigates the immune response and safety of a high-dose influenza vaccine in adults aged 50 to 64 years. Influenza, commonly known as the flu, is a contagious respiratory illness caused by influenza viruses. The study aims to understand how well the immune system responds to the vaccine and …
This study investigates the safety and immune response of an investigational vaccine for preventing lower respiratory tract disease caused by human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) in adults aged 60 years and older. Lower respiratory tract disease affects the lungs and can cause symptoms like coughing and difficulty …
This study investigates the safety and immune response of a combined influenza and COVID-19 vaccine in adults aged 50 years and older. The study will compare different combinations of an investigational influenza vaccine and an investigational COVID-19 vaccine. Participants will receive either the combined vaccines or one of the vaccines …
This study investigates the safety and immune response of combining a high-dose flu vaccine with a COVID-19 vaccine in adults aged 50 and older. The study will compare different levels of the COVID-19 vaccine's spike protein with the flu vaccine alone, the COVID-19 vaccine alone, and both vaccines given in …
This study investigates the safety and early effectiveness of an investigational medication used alone or with other cancer treatments. It is for adults aged 18 and older who have advanced solid tumors that cannot be surgically removed or have spread to other parts of the body. The study has two …
