This study investigates the effects of an investigational medication in children with chronic graft versus host disease (cGVHD). The study is open to children aged 1 to 18 years who have moderate to severe cGVHD that has not responded to at least two previous treatments.Participants will receive the investigational medication …
This study investigates the effects of an investigational medication in adults with relapsing forms of multiple sclerosis (MS). The purpose of the study is to compare the annualized relapse rate (ARR) of participants taking the investigational medication versus those taking a daily oral dose of another medication.Participants will undergo regular …
This study investigates the efficacy and safety of an investigational medication in individuals aged 10 to 65 years with sickle-cell disease (SCD). The study is divided into two parts: a double-blind period where neither the participants nor the researchers know who is receiving the investigational medication or a placebo, and …
This study investigates the safety and efficacy of an investigational gene therapy for individuals with non-congenital myotonic dystrophy type 1 (DM1). The purpose of this study is to assess how well the investigational therapy can reduce levels of a specific protein linked to DM1 and improve muscle function in participants …
This study investigates the effectiveness of adding an investigational medication to the treatment regimen of patients with uncontrolled asthma. Uncontrolled asthma refers to patients who continue to experience frequent symptoms despite their current medication. The study compares two treatment arms: one where participants receive the investigational medication along with their …
This study investigates the efficacy and safety of an investigational medication in individuals with moderately to severely active Crohn's Disease (CD). The purpose of this study is to understand how the investigational medication can affect the symptoms and progression of CD.The study involves several procedures, including randomization, which means participants …
This study investigates the long-term safety and efficacy of an investigational medication in adults with asthma. This study is for participants who have completed previous related studies and aims to continue observing the effects of the investigational medication over an extended period.Participants will continue to receive their asthma treatment as …
This study investigates the effectiveness and safety of an investigational medication for adults with chronic pruritus of unknown origin (CPUO). The study includes two parallel-treatment, double-blind, Phase 3 trials (Study A and Study B) designed to compare the investigational medication with a placebo in participants aged 18 to 90 years.Participants …
This study investigates the efficacy and safety of an investigational medication for subcutaneous injection in participants aged 12 years and older with moderate-to-severe atopic dermatitis (AD). The study involves participants who have not responded adequately to previous biologic or oral JAK inhibitor therapies, and who are currently using topical corticosteroids …
This study investigates the effects of an investigational medication given subcutaneously on airway inflammation in people with Chronic Obstructive Pulmonary Disease (COPD). The purpose of this study is to compare the investigational medication with a placebo, which is a substance that looks like the investigational medication but does not contain …
