This study investigates the safety and effectiveness of a one-time intravitreal dose of an investigational medication in adults with neovascular age-related macular degeneration (nAMD). The study is conducted in two parts: Part I involves evaluating different dose levels in successive groups of participants, while Part II involves randomizing participants to …
This study investigates the effects of a single oral dose of an investigational medication on cardiac repolarization in healthy adults. The study is a Phase 1 trial, meaning it is an early stage of testing, and involves several different treatment arms to compare the investigational medication with a placebo and …
This study investigates an investigational medication for children with eosinophilic esophagitis (EoE). EoE causes inflammation that can make it hard for children to eat and get proper nutrition.The purpose of this study is to evaluate how safe and effective the investigational medication is for children with active EoE. Researchers will …
This study investigates the outcomes for mothers and their babies when the mothers receive the investigational vaccine during pregnancy. The focus is on understanding how the vaccine affects maternal health, pregnancy progress, and the newborn's health. Outcomes will be closely monitored to gather important data on these aspects.Participants in the …
This study investigates chronic inflammatory demyelinating polyneuropathy (CIDP), focusing on individuals with residual impairment or disability after receiving standard treatments for at least three months. The purpose of this observational study is to collect data on people with CIDP to better understand how treatments work in real-world settings.Participants will continue …
This study investigates eosinophilic esophagitis (EoE) in patients who have been recently prescribed an investigational medication as part of their standard care.The focus of this study is to observe how this medication is used in routine care and gather information on the condition's impact on patients' feelings, symptoms, and daily …
This study investigates the use of isatuximab combined with other novel agents in people who have relapsed or refractory myeloma.The purpose of this study is to evaluate how safe and effective the combination of isatuximab with novel agents is for treating relapsed or refractory myeloma. This study will look at …
This study investigates the effectiveness and safety of an investigational medication for adults with chronic pruritus of unknown origin (CPUO). The study aims to evaluate how well the investigational medication works and how safe it is for people with CPUO. The focus is on understanding its impact on the severity …
This study investigates the safety and preliminary effectiveness of an investigational medication for adults with advanced solid tumors that cannot be surgically removed or have spread to other parts of the body. The study consists of two parts: a dose escalation phase to find the appropriate dose of the investigational …
This study investigates nonrelapsing secondary progressive multiple sclerosis (nrSPMS). The purpose of this study is to see how well an investigational medication works in slowing down the progression of disability in people with nrSPMS.Participants will be randomly assigned to receive either the investigational medication or a placebo, which is an …
