This study investigates advanced solid tumors, focusing on the safety of an investigational medication, a type of antibody-drug conjugate (ADC), in participants with these challenging-to-treat cancers.Participants will take part in a study with five different parts. Parts A and B will focus on determining the appropriate dosage of the investigational …
This study investigates the efficacy and safety of an investigational medication in patients with moderate to severe Crohn's disease. The study aims to compare different doses of the investigational medication with a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine.Participants …
This study investigates the safety and preliminary effectiveness of an investigational medication for adults with advanced solid tumors that cannot be surgically removed or have spread to other parts of the body. The study consists of two parts: a dose escalation phase to find the appropriate dose of the investigational …
This study investigates the effects of investigational medications on primary focal segmental glomerulosclerosis (FSGS) and primary minimal change disease (MCD). The purpose of this study is to compare how frexalimab, brivekimig, and rilzabrutinib affect protein levels in the urine and remission rates of nephrotic syndrome in participants aged 16 to …
This study investigates the effects of an investigational medication on adults with nonrelapsing secondary progressive multiple sclerosis (nrSPMS). The purpose is to assess how well the investigational medication works in delaying disability progression compared to a placebo. Participants in this study are adults aged 18 to 60 years with nrSPMS.Participants …
The purpose of this study is to investigate the effectiveness of adding an investigational medication to a medium dose of inhaled corticosteroid and long-acting beta-agonist (ICS/LABA) in patients with uncontrolled asthma. Uncontrolled asthma means that patients are still experiencing frequent symptoms despite taking their current asthma medication. This study aims …
This study investigates the effects of an investigational medication in children with chronic graft versus host disease (cGVHD). The study is open to children aged 1 to 18 years who have moderate to severe cGVHD that has not responded to at least two previous treatments.Participants will receive the investigational medication …
This study investigates the safety and effectiveness of an investigational gene therapy in people aged 10 to 50 years with non-congenital myotonic dystrophy type 1 (DM1). The purpose of this study is to assess how well the therapy can reduce the levels of a specific protein related to the disease …
This study investigates the safety and efficacy of an investigational medication in patients aged 10 to 65 years with sickle-cell disease (SCD). The study consists of two parts: a double-blind period where neither the participants nor the researchers know who is receiving the investigational medication or a placebo, and an …
The purpose of this study is to investigate the efficacy and safety of an investigational medication in individuals with moderately to severely active Crohn's Disease (CD). This study is designed to understand how well the investigational medication works and its safety profile in treating CD.Participants in this study will undergo …
