This study investigates the use of an investigational medication in children with chronic Graft Versus Host Disease (cGVHD). The study is open to children aged 1 to less than 18 years who have moderate to severe cGVHD that has not improved after at least two other treatments. The study is …
This study investigates the efficacy and safety of an investigational medication in people with moderately to severely active Crohn's Disease (CD). The study is divided into three sub-studies to evaluate how well the medication works and how safe it is for participants.Participants in the study may undergo several procedures, including …
This study investigates the efficacy and safety of an investigational medication in individuals with moderately to severely active Crohn's Disease. The study involves a comparison between the investigational medication and a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine.Participants will …
This study investigates advanced solid tumors, focusing on the safety of an investigational medication, a type of antibody-drug conjugate (ADC), in participants with these challenging-to-treat cancers.Participants will take part in a study with five different parts. Parts A and B will focus on determining the appropriate dosage of the investigational …
The purpose of this study is to investigate the effectiveness of adding an investigational medication to the current treatment of patients with uncontrolled asthma. Uncontrolled asthma means patients continue to experience frequent symptoms despite their current medication.Participants in this study will either receive the investigational medication along with their inhaled …
This study investigates the efficacy and safety of an investigational medication for patients with sickle-cell disease (SCD). The study is divided into two parts: a double-blind period and an open-label period, with participants randomly assigned to receive either the investigational medication or a placebo.Participants will undergo various study procedures, including …
This study investigates the treatment of Crohn's disease, focusing on evaluating the effectiveness of different doses of an investigational medication compared to a placebo in individuals with moderate to severe Crohn's disease.Participants will be randomly assigned to one of three study arms, receiving either the investigational medication or a placebo. …
This study investigates the safety and initial effectiveness of SAR445877, an investigational medication, in adults with advanced solid tumors. These tumors are either unresectable or metastatic, meaning they cannot be removed with surgery or have spread to other parts of the body. The study is divided into two parts: the …
This study investigates the effects and safety of an investigational medication in children aged 2 to less than 6 years who have uncontrolled asthma or severe asthmatic wheeze. The purpose is to understand how well the medication works and how safe it is for long-term use in this age group. …
This study investigates primary focal segmental glomerulosclerosis (FSGS) and primary minimal change disease (MCD). The purpose of this study is to evaluate how different investigational medications impact proteinuria and the remission rates of nephrotic syndrome in participants aged 16 to 75 years.Participants in this study will be randomly assigned to …
