This study investigates the effectiveness and safety of an investigational medication compared to a placebo for treating chronic lung allograft dysfunction (CLAD) in adults. Participants will have already undergone a bilateral lung transplant and will be receiving a standard treatment regimen including azithromycin and immunosuppression therapies.Participants in the study will …
This study investigates the efficacy and safety of an investigational medication in people with moderately to severely active ulcerative colitis. The purpose is to maintain the health of participants who have previously responded to treatment. This study aims to assess how well participants continue to manage symptoms like abdominal pain …
This study investigates the efficacy and safety of an investigational medication in people with moderately to severely active Ulcerative Colitis (UC). Participants will be in the study for up to 35 weeks. The study includes different sub-studies, each lasting up to 12 weeks, with a follow-up period for those not …
This study investigates the safety of an investigational pneumococcal vaccine in healthy infants aged approximately 2 months. The purpose is to compare this investigational vaccine with a licensed 20-valent pneumococcal conjugate vaccine. Participants will be in the study for about 19 months. During this time, the investigational vaccine or the …
This study investigates the long-term effects of an investigational medication in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose is to evaluate safety, tolerability, and effectiveness over time. Participants will be in the study for up to 56 weeks, including 52 weeks of treatment and 4 weeks of …
This study investigates the effects of an investigational medication on people with chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of this study is to evaluate how well two different dosing regimens of the investigational medication work in comparison to a placebo, when added to standard intranasal corticosteroids, in adults …
This study investigates the efficacy, safety, and tolerability of an investigational medication in participants with chronic rhinosinusitis with nasal polyps (CRSwNP). The study aims to compare two dosing regimens of the investigational medication with a placebo, in addition to standard treatment with intranasal corticosteroids.Participants will undergo a series of procedures …
This study investigates the safety and effectiveness of a one-time intravitreal dose of an investigational medication in adults with neovascular age-related macular degeneration (nAMD). The study is conducted in two parts: Part I involves evaluating different dose levels in successive groups of participants, while Part II involves randomizing participants to …
This study investigates the pharmacokinetics and safety of an investigational medication in children aged 6 months to under 18 years with prurigo nodularis. The purpose of the study is to understand how the investigational medication is processed in the body and to assess its safety for the participants.Participants in the …
This study investigates the effects of a single oral dose of an investigational medication on cardiac repolarization in healthy adults. The study is a Phase 1 trial, meaning it is an early stage of testing, and involves several different treatment arms to compare the investigational medication with a placebo and …
