Inclusion criteria:

• Capable of giving signed informed consent.
• Participant is diagnosed with GD type Ⅲ
• Participant with neurological manifestations
• Participant whose age is > 2 years old.
• Participant whose spleen and/or liver volume is > ULN at Screening.

Exclusion criteria:

• Major congenital anomaly
• Clinically significant intercurrent organic disease unrelated to Gaucher disease, which means the disease or condition that may have impact on the parameters chosen for primary endpoints (e.g. level of hemoglobin platelets, liver/spleen enlargement and bone pains)
• Prior treatment with ERT.
• Physical conditions that cannot tolerate regular treatment or follow-up visit.
• Pregnant or lactating women
• Participant is participating in or has participated in another clinical study using any investigational therapy in 3 months
• Participant has been diagnosed with central nervous system disease unrelated to Gaucher disease, or MRI result of the participant indicates space-occupying lesion in central nervous system
• The patient has a documented hemoglobinopathies, deficiency of iron, vitamin B-12, or folate that requires treatment not yet initiated or, if initiated, the patient has not been stable under treatment for at least 6 months prior to administration of the first dose of Cerezyme in this study
• Participant not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to study procedures
• Any specific situation during study implementation/course that may rise ethics considerations
• Sensitivity to any of the study interventions, or components thereof, or drug or other allergy that, in the opinion of the Investigator, contraindicates participation in the study

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.