This study investigates the effects of an investigational medication on children and adolescents with Systemic Juvenile Idiopathic Arthritis (sJIA). The purpose of this study is to understand how the body processes the investigational medication and to determine the appropriate dose for treating sJIA.Participants will undergo various procedures to assess the …
This study investigates the efficacy and safety of an investigational medication in patients with moderate to severe Crohn's disease. The study aims to compare different doses of the investigational medication with a placebo, which is an inactive substance that looks like the investigational medication but does not contain any medicine.Participants …
This study investigates the safety and preliminary effectiveness of an investigational medication for adults with advanced solid tumors that cannot be surgically removed or have spread to other parts of the body. The study consists of two parts: a dose escalation phase to find the appropriate dose of the investigational …
This study investigates the effects of investigational medications on primary focal segmental glomerulosclerosis (FSGS) and primary minimal change disease (MCD). The purpose of this study is to compare how frexalimab, brivekimig, and rilzabrutinib affect protein levels in the urine and remission rates of nephrotic syndrome in participants aged 16 to …
This study investigates the effects of an investigational medication on adults with nonrelapsing secondary progressive multiple sclerosis (nrSPMS). The purpose is to assess how well the investigational medication works in delaying disability progression compared to a placebo. Participants in this study are adults aged 18 to 60 years with nrSPMS.Participants …
This study investigates the effects of an investigational medication in children with chronic graft versus host disease (cGVHD). The study is open to children aged 1 to 18 years who have moderate to severe cGVHD that has not responded to at least two previous treatments.Participants will receive the investigational medication …
This study investigates the safety and efficacy of an investigational medication in patients aged 10 to 65 years with sickle-cell disease (SCD). The study consists of two parts: a double-blind period where neither the participants nor the researchers know who is receiving the investigational medication or a placebo, and an …
This study investigates the effects of an investigational medication in adults with relapsing forms of multiple sclerosis (MS). The purpose of the study is to compare the annualized relapse rate (ARR) of participants taking the investigational medication versus those taking a daily oral dose of another medication.Participants will undergo regular …
This study investigates an investigational medication for metastatic castration resistant prostate cancer (mCRPC). The purpose of this study is to understand the safety, how the body processes the investigational medication, and its preliminary effectiveness in treating mCRPC.Participants in the study will receive the investigational medication in different parts. Initially, there …
This study investigates the clinical outcomes of patients with Gaucher disease. The study is observational, meaning it collects data from patients receiving routine care without altering their treatment. It aims to enhance understanding of the disease's variability, progression, and natural history to aid in better therapeutic interventions.Participants will undergo clinical …
