This study investigates the effects of an investigational medication given as a shot under the skin for people with severe alopecia areata, a condition causing hair loss. Alopecia areata is when the immune system attacks hair follicles, leading to hair loss. The study includes adults aged 18 and older who …
This study investigates the effectiveness of an investigational medication in kidney transplant patients. It focuses on two groups: Cohort A, which includes patients with chronic kidney disease receiving a kidney transplant from a donor they are sensitized to, and Cohort B, which includes kidney transplant recipients diagnosed with active antibody-mediated …
This study investigates the treatment of moderate-to-severe rheumatoid arthritis (RA) in adults who have not responded adequately to methotrexate (MTX). Rheumatoid arthritis is a chronic inflammatory disorder affecting joints, causing pain and swelling. The study will assess the safety and effectiveness of an investigational medication compared to a placebo, which …
This study investigates the effects of an investigational medication compared to a placebo in adults with moderate to severe hidradenitis suppurativa (HS). HS is a chronic skin condition characterized by painful lumps under the skin, often in areas where skin rubs together. The study aims to understand how the investigational …
This study investigates the efficacy and safety of an investigational medication compared to a placebo in patients who have had a bilateral lung transplant. The condition being studied is chronic lung allograft dysfunction (CLAD), which is a condition where the lungs do not function properly after a transplant. Participants in …
This study investigates the effects of an investigational medication compared to a placebo in treating adults with active Systemic Lupus Erythematosus (SLE). SLE is a chronic autoimmune disease where the body's immune system attacks its own tissues, causing inflammation and damage. Participants in this study will be between the ages …
This study investigates the treatment of Systemic Juvenile Idiopathic Arthritis (sJIA) in children and adolescents aged 1 to 17 years. Systemic Juvenile Idiopathic Arthritis is a type of arthritis that causes joint inflammation and fever in children. The purpose of this study is to understand how the investigational medication moves …
This study investigates the effects of an investigational medication on individuals with infantile-onset Pompe disease (IOPD). IOPD is a rare genetic disorder caused by the buildup of glycogen in the body's cells, leading to muscle weakness and heart problems. The study aims to understand how the investigational medication works in …
This study investigates the effects of an investigational medication on chronic pruritus of unknown origin (CPUO) in adults. Chronic pruritus is a condition characterized by persistent itching without a known cause. The study involves two separate but similar trials, each testing the medication against a placebo, which is an inactive …
This study investigates the safety and effects of an investigational medication in people with HER2+ tumors. HER2+ tumors are a type of cancer where there is an overexpression of the human epidermal growth factor receptor 2, which can promote the growth of cancer cells. The study will test the investigational …
