Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab in Pretreated Participants With Gastric Cancer (CARMEN-GC01)

Study Overview

Primary Objectives:

Part 1: to confirm the recommended tusamitamab ravtansine loading dose Q2W in combination with ramucirumab in advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma population

Part 2: to assess the antitumor activity of tusamitamab ravtansine loading dose Q2W in combination with ramucirumab in advanced gastric or GEJ adenocarcinoma

Secondary Objectives:

  • To assess safety
  • To assess durability
  • To assess progression-free survival (PFS)
  • To assess the disease control rate (DCR)
  • To assess the pharmacokinetics (PK)
  • To assess the immunogenicity

Study details

34 weeks (up to 4 weeks for screening, a median of 18 weeks for treatment, and a median of 12 weeks for end-of-treatment assessments and the safety follow-up visit).

Eligibility Criteria

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Adenocarcinoma Gastric, Gastrooesophageal Cancer
  • Age: 18 Years
  • Gender: All

Inclusion Criteria:

  • Histologically or cytologically confirmed diagnosis of gastric or GEJ adenocarcinoma
  • Metastatic disease or locally advanced, unresectable disease
  • Participants who have measurable target lesion
  • Participants with high carcinoembryonic antigen-related cell adhesion molecule (CEACAM5) expression as per central assessment on tumor biospsy
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-1
  • Female participant who agrees to use effective contraceptive methods during and for at least 7 months after the last dose of treatment administration
  • Male participant who agrees to use effective contraception methods during and for at least 4 months after the last dose of treatment administration
  • Signed informed consent

Exclusion Criteria:

  • Untreated brain metastases, leptomeningeal disease, or uncontrolled spinal cord compression
  • Significant concomitant illness
  • History within the last 3 years of an invasive malignancy other than that treated in this study
  • Known uncontrolled infection
  • Nonresolution of any prior treatment-related toxicity
  • Unresolved corneal disorder or any previous corneal disorder considered by an ophthalmologist to predict higher risk of drug-induced keratopathy
  • Use of contact lenses
  • Radiographic evidence of major airway or blood vessel invasion or intratumor cavitation
  • History of uncontrolled hereditary or acquired thrombotic disorder or history of aneurism
  • Major surgery within 28 days prior to Day 1/first IMP infusion; subcutaneous venous access device placement within 7 days prior to Day 1; or postoperative bleeding complications or wound complications from a surgical procedure performed in the last 2 months
  • History of gross hemoptysis (defined as bright red blood or ≥1/2 teaspoon) within 2 months before the first treatment administration
  • Any arterial thrombotic event, including myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack, within 6 months before the first administration of treatment administration
  • Uncontrolled arterial hypertension (systolic ≥150 mmHg or diastolic ≥90 mmHg) despite standard medical management.
  • Serious or nonhealing wound, skin ulcer, or bone fracture within 28 days before the first administration of treatment administration
  • Gastrointestinal (GI) perforation and/or fistulae within 6 months prior to first administration of treatment administration
  • Significant bleeding disorders, vasculitis, or Grade 3-4 gastrointestinal (GI) bleeding within 3 months before the first administration of study intervention.
  • Bowel obstruction, history or presence of inflammatory enteropathy or extensive intestinal resection Crohn's disease, ulcerative colitis, or chronic diarrhea
  • Medical condition requiring concomitant administration of a medication with a narrow therapeutic window and metabolized by CYP450 or a strong CYP3A inhibitor
  • Concurrent treatment with any other anticancer therapy
  • Prior treatment targeting CEACAM5 or containing maytansinoid DM1 or DM4 or ramucirumab or taxane or targeting VEGF/VEGFR Poor organ function
        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.

Updated on 08 Feb 2024. Study ID: NCT05071053