This study investigates the efficacy and safety of an investigational medication in delaying disability progression in individuals with non-relapsing secondary progressive multiple sclerosis (nrSPMS). nrSPMS is a stage of multiple sclerosis (MS) where symptoms worsen over time without periods of remission. Participants will be randomly assigned to receive either the …
This study investigates the treatment of newly diagnosed moderate or severe chronic graft-versus-host disease (cGVHD). Chronic GVHD is a condition that can occur after a stem cell or bone marrow transplant, where the donated cells attack the recipient's body. The study aims to assess the effectiveness of an investigational medication …
This study investigates the efficacy and safety of an investigational medication compared to a placebo in patients who have undergone a bilateral lung transplant and have chronic lung allograft dysfunction (CLAD). CLAD is a condition where the lung function declines over time after a transplant. Participants must be at least …
This study investigates the safety and ability of an investigational pneumococcal vaccine to stimulate the body's defense system in infants. The study compares this investigational vaccine with a licensed pneumococcal vaccine when given alongside routine vaccines to infants aged about 2 months. The investigational vaccine is being tested to see …
This study investigates the effects of an investigational medication on people with chronic rhinosinusitis with nasal polyps (CRSwNP). CRSwNP is a condition where the lining of the nasal passages and sinuses becomes swollen, leading to the growth of polyps. The study will compare two different dosing regimens of the investigational …
This study investigates the use of an investigational medication in combination with other agents to treat individuals with relapsed or refractory myeloma. Myeloma is a type of cancer that affects plasma cells in the bone marrow, leading to issues such as bone pain, anemia, and infections. The study includes multiple …
This study investigates the safety and effects of an investigational medication in people with blood cancers such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). These are conditions where the blood and bone marrow make abnormal blood cells. The study aims to understand how the body processes the medication …
This study investigates the safety and effects of an investigational medication in people with HER2+ tumors, which are tumors that have a protein called Human Epidermal Growth Factor Receptor 2. This protein can promote the growth of cancer cells and is found in some types of cancer. The study is …
This study investigates the safety and effectiveness of an investigational medication in people with moderate to severe atopic dermatitis (AD). Atopic dermatitis is a skin condition that causes red, itchy, and inflamed skin. Participants in this study have previously been treated with the investigational medication in earlier trials. The study …
This study investigates the long-term safety and how well an investigational medication works in people with moderate to severe atopic dermatitis (AD). Atopic dermatitis is a skin condition that causes itchy and inflamed skin. The study is for participants who are 12 years or older.Participants will receive the investigational medication …
