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A Phase 1/Phase 2 Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Intravenous Administration of SAR444836 in Adult Participants With Phenylketonuria
Gene Therapy Study for Phenylketonuria
Recruiting
18 years - 65 years
All
Phase
1/2
32 participants needed
6 Locations
Study Overview
This is a single group Phase 1/Phase 2, 1-arm, open-label study with SAR444836, an adeno-associated virus (AAV) vector-mediated gene transfer of human phenylalanine hydroxylase (PAH), for the treatment of adult participants with phenylketonuria (PKU) on a chronic, stable diet. The purpose of the study is to evaluate the safety and efficacy of SAR444836 in reducing phenylalanine (Phe) levels and in the elimination of a Phe restricted diet.
Participants will receive a one-time intravenous (IV) administration of SAR444836.
The study is constituted of 2 separate parts: a dose escalation part, and a dose expansion part where subsequent participants will be administered a safe and effective dose level identified during the dose escalation part. In both study parts, clinical and laboratory assessments will be collected to: a) assess the incidence of adverse events, and b) evaluate the effect of SAR444836 on reductions in blood Phe levels and maintenance of these Phe levels after elimination of a Phe restricted diet.
The study duration will be for a minimum duration of 5 years following SAR444836 administration, for each participant and includes a 6-week screening phase, a 96-week treatment follow-up period after SAR444836 administration, followed by an additional 3 years of long-term safety (and efficacy) monitoring.
There will be a total of 47 study visits. Many study visits may occur as remote visits and be performed by a qualified in-home service provider.
Actual study duration for an individual participant may be longer than 5 years due to the administration of SAR444836 to participants in Stage 1A in a serial fashion, the duration of the screening period, and/or other factors such as delays in scheduling study visits.
Eligibility Criteria
You may be eligible for this study if you meet the following criteria:
- Conditions: Phenylketonuria
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Age: 18 years - 65 years
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Gender: All
Inclusion Criteria:
- Adult males, and females of non-childbearing potential, 18-65 years of age at the time of informed consent.
- Participants must have uncontrolled classical PKU due to PAH deficiency (despite Phe-restricted dietary management or Palynziq) in the judgement of the Investigator.
- Two historical plasma Phe values ≥ 600 μmol/L in the preceding 12 months while on Phe restricted diet therapy. Two plasma Phe values ≥ 600 μmol/L drawn at least 72 hours apart during the screening period while on Phe restricted diet therapy in the absence of an acute illness.
- Participant has the ability and willingness to maintain their present diet for the duration of the Post-treatment Follow-up Phase (through Week 96), unless otherwise directed as per protocol
- Body mass index (BMI) ≤ 35 kg/m2
- Willingness to use effective methods of contraception.
- Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
Exclusion Criteria:
- Presence of neutralizing antibodies against the AAV SNY001 capsid
- Abnormal liver function laboratory testing evidenced by alanine aminotransferase (ALT)>1.5X upper limit normal (ULN), aspartate transaminase (AST)>1.5X ULN, alkaline phosphatase >1.5X ULN, Total and direct bilirubin >1.5X ULN (bilirubin levels above the laboratory's normal range are acceptable in individuals with a documented history or laboratory evidence of Gilbert's Disease)
- Any significant underlying liver disease or any of the following documented
diagnoses, indicative of significant underlying liver disease:
- Portal hypertension; or
- Splenomegaly; or
- Hepatic encephalopathy
- Serum albumin measurement below the lower limit of normal of the laboratory OR
AST-to-Platelet Ratio Index > 1.0
- Serum creatinine >1.5X ULN
- Hemoglobin A1c >6.5% or fasting glucose >126 mg/dL
- Screening laboratory testing demonstrating any of the following:
- HIV; or
- active or prior hepatitis B virus (HBV) infection defined as positive test for hepatitis B surface antigen (HBsAg) or positive test for hepatitis B core antibody (total HBcAb) or detectable HBV DNA; or
- active hepatitis C virus (HCV) infection defined as positive test for hepatitis C antibody followed by detectable HCV RNA or if a participant is presently receiving (or has received within 6 months prior to screening) anti-viral therapy for hepatitis C
- Clinically significant, active bacterial, viral, fungal, or parasitic infection
(based on Investigator's judgement)
The above information is not intended to contain all considerations relevant to a potential participation in a clinical trial.
Updated on
08 May 2025.
Study ID: NCT05972629
This study investigates the use of an investigational gene therapy for adults with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine (Phe). The purpose of this study is to see if the investigational treatment can safely reduce Phe levels and allow participants to stop following a Phe-restricted diet. Participants will receive a one-time intravenous (IV) dose of the investigational therapy, which uses a virus to deliver a gene that may help the body process Phe.
The study has two parts: dose escalation and dose expansion. In the dose escalation part, participants receive different doses to find a safe amount. The dose expansion part uses the safest dose for new participants. Throughout the study, participants will have clinical and lab tests to check for side effects and see if the treatment reduces Phe levels and maintains them without a special diet.
- Who can participate: Adults aged 18 to 65 with uncontrolled classical PKU due to PAH deficiency can participate. They must have certain Phe levels despite diet management and be willing to maintain their current diet.
- Study details: Participants will receive a one-time IV dose of the investigational gene therapy. They will need to follow their current diet unless advised otherwise by the study protocol. A placebo is not used in this study.
- Study Timelines and Visits: The study will last approximately 102 weeks. The study requires 41 visits.
Pre-Screener
