This study investigates the use of an investigational gene therapy for adults with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine (Phe). The purpose of this study is to see if the investigational treatment can safely reduce Phe levels and allow participants to …
This study investigates the effects of an investigational medication compared to an existing treatment in people with relapsing forms of multiple sclerosis, a condition where the immune system mistakenly attacks the protective covering of the nerves, causing communication problems between the brain and the rest of the body. The study …
This study investigates the efficacy and safety of an investigational medication in delaying disability progression in individuals with non-relapsing secondary progressive multiple sclerosis (nrSPMS). nrSPMS is a stage of multiple sclerosis (MS) where symptoms worsen over time without periods of remission. Participants will be randomly assigned to receive either the …
This study investigates the treatment of newly diagnosed moderate or severe chronic graft-versus-host disease (cGVHD). Chronic GVHD is a condition that can occur after a stem cell or bone marrow transplant, where the donated cells attack the recipient's body. The study aims to assess the effectiveness of an investigational medication …
This study investigates the treatment of moderate-to-severe atopic dermatitis (AD), a skin condition causing itchy and inflamed skin, in individuals who have not responded well to topical treatments. The purpose of this study is to compare the safety and effectiveness of an investigational medication given by injection to a placebo, …
This study investigates the effectiveness and safety of an investigational medication compared to a placebo in adults with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) who do not respond to available treatments. CIDP is a condition where the body's immune system mistakenly attacks the protective covering of the nerves, leading to weakness …
This study investigates the effectiveness and safety of an investigational medication compared to intravenous immunoglobulin (IVIg) in adults with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). CIDP is a neurological disorder that causes weakness and sensory loss due to inflammation of the peripheral nerves. The purpose of this study is to assess …
This study investigates the effectiveness and safety of an investigational medication for treating Non-Cystic Fibrosis Bronchiectasis (NCFB). NCFB is a lung condition where the airways become widened and scarred, leading to symptoms like a persistent cough, production of sputum, and frequent lung infections. The study will compare two different dosing …
This study investigates the effect of an investigational medication compared to standard care in preventing or slowing the decline of lung function in adults with uncontrolled moderate to severe asthma. Asthma is a condition where the airways in the lungs become inflamed and narrow, making it hard to breathe. The …
This study investigates the safety and effectiveness of an investigational medication in people with moderate to severe atopic dermatitis (AD). Atopic dermatitis is a skin condition that causes red, itchy, and inflamed skin. Participants in this study have previously been treated with the investigational medication in earlier trials. The study …
