This study investigates the effects of an investigational medication on preventing or slowing lung function decline in adults with uncontrolled moderate to severe asthma. Participants in this study will be randomly assigned to one of two study arms: one receiving the investigational medication and the other receiving standard care therapy.Participants …
This study investigates the efficacy and safety of an investigational medication for moderate-to-severe atopic dermatitis (AD) in participants aged 12 years and older. The study involves participants who have not responded adequately to previous biologic therapies or oral JAK inhibitors, and they will continue using topical corticosteroids (TCS) during the …
This study investigates the long-term safety and effects of an investigational medication in adults with asthma. The purpose of this study is to evaluate how safe and effective the investigational medication is for adults who have completed previous related studies.Participants in the study will continue their treatment with the investigational …
The purpose of this study is to investigate airway inflammation in individuals with Chronic Obstructive Pulmonary Disease (COPD). This study will compare the effects of an investigational medication and a placebo on airway inflammation, resistance, and remodeling, which includes mucus plugging. It will also examine how these factors relate to …
This study investigates the efficacy, safety, and tolerability of an investigational medication administered subcutaneously compared to a placebo in adults with inadequately controlled Chronic Obstructive Pulmonary Disease (COPD) characterized by an eosinophilic phenotype.Participants will receive subcutaneous administrations of either the investigational medication or a matching placebo over a 48-week period. …
This study investigates the effects of an investigational medication compared to a placebo in adults with Chronic Obstructive Pulmonary Disease (COPD) that has an eosinophilic phenotype, characterized by a higher number of eosinophils, a type of white blood cell. The purpose of this study is to evaluate the efficacy, safety, …
This study investigates the effects and safety of an investigational medication in children aged 2 to less than 6 years who have uncontrolled asthma or severe asthmatic wheeze. The purpose is to understand how well the medication works and how safe it is for long-term use in this age group. …
This study investigates the long-term safety and tolerability of an investigational medication in adults with different forms of multiple sclerosis, including relapsing MS (RMS), primary progressive MS (PPMS), and non-relapsing secondary progressive MS (NRSPMS).Participants in this study will continue to receive the investigational medication in an open-label format, meaning both …
This study investigates the effects of investigational medications on primary focal segmental glomerulosclerosis (FSGS) and primary minimal change disease (MCD). The purpose of this study is to compare how frexalimab, brivekimig, and rilzabrutinib affect protein levels in the urine and remission rates of nephrotic syndrome in participants aged 16 to …
This study investigates the effects of an investigational medication on adults with nonrelapsing secondary progressive multiple sclerosis (nrSPMS). The purpose is to assess how well the investigational medication works in delaying disability progression compared to a placebo. Participants in this study are adults aged 18 to 60 years with nrSPMS.Participants …
