This study investigates the effects of an investigational medication in adults with non-responsive celiac disease (NRCD) who follow a gluten-free diet. This study aims to understand how the investigational medication affects intestinal damage caused by gluten exposure, as measured by the villous height to crypt depth ratio, and its impact …
This study investigates the efficacy and safety of an investigational medication in adults with moderate to severe Crohn's Disease (CD). This study compares different doses of the investigational medication with a placebo to determine its effectiveness in managing CD symptoms.Participants will undergo various study procedures, including a Double-Blind (DB) treatment …
This study investigates the efficacy and safety of an investigational medication in adults with nonrelapsing secondary progressive multiple sclerosis (nrSPMS). The purpose of this study is to determine whether the investigational medication can delay disability progression compared to a placebo.Participants in this randomized, double-blind, placebo-controlled study will receive either the …
This study investigates the efficacy and safety of an investigational medication given as a subcutaneous injection for individuals aged 12 years and older with moderate-to-severe atopic dermatitis (AD). The study focuses on participants who have not responded adequately to prior biologic therapies or oral JAK inhibitors, while continuing their topical …
This study investigates the effects of an investigational medication on people with Type 1 diabetes. The study aims to assess the safety and efficacy of the investigational medication compared to a placebo to help preserve the function of β-cells in the pancreas.Participants will be randomly assigned to one of two …
This study investigates the effectiveness and safety of an investigational medication compared to a placebo in treating chronic lung allograft dysfunction (CLAD) in adults who have had a lung transplant. Participants in this study must have had their transplant at least a year ago and must be experiencing progression of …
This study investigates the safety and ability of an investigational pneumococcal conjugate vaccine to stimulate the immune system in healthy infants. Infants between 42 and 89 days old will receive either the investigational vaccine or a licensed pneumococcal vaccine, alongside routine pediatric vaccines. The purpose is to compare the immune …
This study investigates the effects of an investigational medication on individuals with chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of this study is to assess the efficacy, safety, and tolerability of two dosing regimens of the investigational medication compared to a placebo, alongside intranasal corticosteroids (INCS).Participants will be randomly …
This study investigates the efficacy and safety of an investigational medication in adults with moderate to severe Ulcerative Colitis. The study compares different doses of the investigational medication to a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine.Participants will be …
This study investigates the use of an investigational medication in combination with other novel agents in participants with relapsed or refractory multiple myeloma (RRMM). The study includes several substudies with different combinations of treatments, some with and some without the drug dexamethasone.Participants in this study will undergo various procedures depending …
