This study investigates the efficacy and safety of an investigational medication in delaying disability progression in individuals with non-relapsing secondary progressive multiple sclerosis (nrSPMS). nrSPMS is a stage of multiple sclerosis (MS) where symptoms worsen over time without periods of remission. Participants will be randomly assigned to receive either the …
This study investigates the effects of an investigational medication for people with moderate-to-severe atopic dermatitis (AD). Atopic dermatitis is a skin condition that causes itchy, inflamed skin. The study focuses on participants aged 12 years and older who have not responded well to previous treatments, including biologic medications or oral …
This study investigates the effects of an investigational medication on adults with non-responsive celiac disease (NRCD) who are on a gluten-free diet. Celiac disease is a condition where eating gluten leads to damage in the small intestine. The study aims to see how the investigational medication affects the small intestine's …
This study investigates the treatment of newly diagnosed moderate or severe chronic graft-versus-host disease (cGVHD). Chronic GVHD is a condition that can occur after a stem cell or bone marrow transplant, where the donated cells attack the recipient's body. The study aims to assess the effectiveness of an investigational medication …
This study investigates the efficacy and safety of an investigational medication compared to a placebo in patients who have undergone a bilateral lung transplant and have chronic lung allograft dysfunction (CLAD). CLAD is a condition where the lung function declines over time after a transplant. Participants must be at least …
This study investigates the safety and ability of an investigational pneumococcal vaccine to stimulate the body's defense system in infants. The study compares this investigational vaccine with a licensed pneumococcal vaccine when given alongside routine vaccines to infants aged about 2 months. The investigational vaccine is being tested to see …
This study investigates the effects of an investigational medication on people with chronic rhinosinusitis with nasal polyps (CRSwNP). CRSwNP is a condition where the lining of the nasal passages and sinuses becomes swollen, leading to the growth of polyps. The study will compare two different dosing regimens of the investigational …
This study investigates the use of an investigational medication in combination with other agents to treat individuals with relapsed or refractory myeloma. Myeloma is a type of cancer that affects plasma cells in the bone marrow, leading to issues such as bone pain, anemia, and infections. The study includes multiple …
This study investigates the safety and effects of an investigational medication in people with HER2+ tumors, which are tumors that have a protein called Human Epidermal Growth Factor Receptor 2. This protein can promote the growth of cancer cells and is found in some types of cancer. The study is …
This study investigates the safety and effectiveness of an investigational medication in people with moderate to severe atopic dermatitis (AD). Atopic dermatitis is a skin condition that causes red, itchy, and inflamed skin. Participants in this study have previously been treated with the investigational medication in earlier trials. The study …
