This study investigates the safety and efficacy of an investigational medication for individuals aged 12 and older with moderate to severe atopic dermatitis. The study aims to understand how this medication affects participants over a long-term period.Participants will receive the investigational medication through injections under the skin. This open-label study …
This study investigates the efficacy and safety of an investigational medication for moderate-to-severe atopic dermatitis (AD) in participants aged 12 years and older. The study involves participants who have not responded adequately to previous biologic therapies or oral JAK inhibitors, and they will continue using topical corticosteroids (TCS) during the …
This study investigates the safety and efficacy of an investigational medication injected under the skin in adult participants with relapsed or refractory multiple myeloma. This study aims to determine the best dose of the investigational medication for future research.Participants will be involved in two parts of the study. In Part …
This study investigates the efficacy, safety, and tolerability of an investigational medication administered subcutaneously compared to a placebo in adults with inadequately controlled Chronic Obstructive Pulmonary Disease (COPD) characterized by an eosinophilic phenotype.Participants will receive subcutaneous administrations of either the investigational medication or a matching placebo over a 48-week period. …
This study investigates the treatment of Crohn's disease, focusing on evaluating the effectiveness of different doses of an investigational medication compared to a placebo in individuals with moderate to severe Crohn's disease.Participants will be randomly assigned to one of three study arms, receiving either the investigational medication or a placebo. …
This study investigates primary focal segmental glomerulosclerosis (FSGS) and primary minimal change disease (MCD). The purpose of this study is to evaluate how different investigational medications impact proteinuria and the remission rates of nephrotic syndrome in participants aged 16 to 75 years.Participants in this study will be randomly assigned to …
This study investigates an investigational medication for metastatic castration resistant prostate cancer (mCRPC). The purpose of this study is to understand the safety, how the body processes the investigational medication, and its preliminary effectiveness in treating mCRPC.Participants in the study will receive the investigational medication in different parts. Initially, there …
This study investigates the safety, efficacy, and immune response of an investigational mRNA vaccine for adults with moderate to severe acne. This study aims to evaluate how well the vaccine works at different doses in participants aged 18 to 45 years.Participants in the study will receive up to three intramuscular …
This study investigates the clinical outcomes of patients with Gaucher disease. The study is observational, meaning it collects data from patients receiving routine care without altering their treatment. It aims to enhance understanding of the disease's variability, progression, and natural history to aid in better therapeutic interventions.Participants will undergo clinical …
This study investigates Mucopolysaccharidosis I (MPS I), a rare genetic disorder. The purpose of this observational study is to collect data on the natural history and progression of MPS I and to observe clinical responses in patients receiving enzyme replacement therapy or other treatments.Participants in this study will have their …
