This study investigates the efficacy and safety of an investigational medication in adults with moderate to severe Crohn's Disease (CD). The purpose of this study is to compare different doses of the investigational medication with a placebo to assess their effectiveness in managing CD symptoms.Participants in this study will undergo …
This study investigates the efficacy and safety of an investigational medication in adults with moderate-to-severe ulcerative colitis. The purpose of this study is to evaluate how different doses of the investigational medication affect clinical remission in participants with this condition.Participants will be randomly assigned to receive either the investigational medication …
This study investigates the effects of an investigational medication on adults with non-responsive celiac disease, where symptoms persist despite a gluten-free diet. This study aims to evaluate how the investigational medication affects changes in the intestinal lining compared to a placebo, focusing on the villous height to crypt depth ratio, …
This study investigates the effectiveness and safety of an investigational medication compared to a placebo in treating chronic lung allograft dysfunction (CLAD) in adults who have had a lung transplant. Participants in this study must have had their transplant at least a year ago and must be experiencing progression of …
This study investigates the safety and ability of an investigational pneumococcal conjugate vaccine to stimulate the immune system in healthy infants. Infants between 42 and 89 days old will receive either the investigational vaccine or a licensed pneumococcal vaccine, alongside routine pediatric vaccines. The purpose is to compare the immune …
This study investigates chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of this study is to evaluate the effectiveness, safety, and tolerability of two dosing regimens of an investigational medication, compared to a placebo, as an additional treatment to standard intranasal corticosteroids in people with CRSwNP.Participants in the study will …
This study investigates the safety and activity of an investigational medication in patients with relapsed or refractory B-cell Non-Hodgkin Lymphoma (B-NHL). This study aims to find the best dose by examining safety, how the drug moves through the body (pharmacokinetics), how it affects the body (pharmacodynamics), its clinical activity, and …
This study investigates the use of an investigational medication for treating moderate to severe hidradenitis suppurativa (HS). The purpose of this study is to assess the efficacy and safety of different doses of the investigational medication in participants with HS.Participants will be randomly assigned to receive either the investigational medication …
This study investigates the effects of an investigational medication on adults with moderate to severe Ulcerative Colitis. The goal is to compare the effectiveness of different doses of the investigational medication with a placebo. Ulcerative Colitis can lead to symptoms such as abdominal pain, diarrhea, and rectal bleeding, and it …
This study investigates the use of an investigational medication in combination with other novel agents in participants with relapsed or refractory multiple myeloma (RRMM). The study includes several substudies with different combinations of treatments, some with and some without the drug dexamethasone.Participants in this study will undergo various procedures depending …
